Rat Bite Fever Essay -- streptobacillus moniliformis, rna

One of the main causes of the disease known as Rat Bite Fever is from infection by the bacteria Streptobacillus moniliformis. This bacterium is commonly the cause of the disease in North America (Elliot, 2007). This disease is typically difficult to diagnose, leading to a delay in discussion and unnecessary increase in the severity of its symptoms. Cases of rat bite fever be rather rare in North America, and those resulting in death are even less common, making the study of its pathogenesis difficult. In order to better understanding this disease, work is being done to annotate the genome of the bacterium. Gene annotation is a process in which biological information is attached to a single gene or genomic sequence. Oftentimes, this is initially done automatically via computer analysis, and then after is manually annotated. That is the case here, where an automatic annotation has been performed for many of the genes within the S. moniliformis genome (Nolan, 2009), but it is n ecessary to manually annotate the genome in order to better understand the biological processes. The manual annotation includes identifying or confirming the genes role in coding, gene expression, biochemical function, and many other functions (Stein, 2001).Smon_0852 & Smon_0853Smon_0852 is annotated as a Polynucleotide adenylyltransferase region, which is involved in the biological process, RNA processing, and its molecular function is ATP binding, RNA binding, hydrolase activity, and nucleotidyl transferase, according to GO. Pfam identifies that Smon_0852 is a part of the Protein battlegrounds Poly A polymerase head and Nudix family. The Poly A polymerase head domain is involved in adding the poly (A) tail to mRNA (Cao, 1992). The Nudix family is ... ...l structure of NGO0477 from Neisseria gonorrhoeae reveals a novel protein fold incorporating a helix-turn-helix motif. Proteins 781798-1802(2010).Stein, L. (2001). Genome annotation from sequence to biology. Nature Reviews genetics 2 (7) 493503.doi10.1038/35080529. PMID 11433356.Tscherne, J.S., Nurse, K., Popienick, P., Michel, H., Sochacki, M. and Ofengand, J. Purification, cloning, and characterization of the 16S RNA m5C967 methyltransferase from Escherichia coli. Biochemistry 3818841892(1999). Yau, K. Cyclic Nucleotide-gated Channels an expanding new family of ion channels Proc Natl Acad Sci USA. 91(9) 34813483 (1994).Zhang H, Huang K, Li Z, Banerjei L, Fisher KE, Grishin NV, Eisenstein E, Herzberg O, Crystal structure of YbaK protein from Haemophilus influenzae (HI1434) at 1.8 A effect functional implications. Proteins 4086-97(2000).